Automated synthesis with SYNTHIA retrosynthesis software

SYNTHIA™ retrosynthesis software aids chemists in designing synthetic routes, offering ranked potential routes to target molecules, while Synple's cartridge-based synthesis technology automates chemical reactions commonly used in discovery chemistry. Merck KGaA, Darmstadt, Germany, discusses the integration of SYNTHIA retrosynthesis software with Synple Automated Synthesizer to streamline synthetic chemistry processes. It highlights the advancements in technology and automation, including robotic systems, machine learning algorithms, and virtual screening methods, which accelerate molecule discovery and synthesis while minimizing errors. There is also case study comparing different search configurations and demonstrates the quick and efficient synthesis of target molecules using both manual and automated approaches, showcasing the potential of this integrated workflow to accelerate the drug discovery process.