Calcium Retention Capacity Assay Evaluates Inhibition of Mitochondrial Permeability Transition Pore

Mitochondrial dysfunction is central to the pathogenesis of acute pancreatitis as well as other diseases including ischemia-reperfusion injury of the heart, brain and kidney, muscular dystrophies and neurodegeneration. Mitochondrial dysfunction is the result of a sudden increase in permeability of the inner mitochondrial membrane (IMM), via persistent opening of a multi-protein channel known as the mitochondrial permeability transition pore (MPTP).