Combined Measurements of Total and Viable Cell Density for Better Process Understanding and Control Using Hamilton Sensors

Mammalian cell culture processes are very important for the production of various recombinant proteins for clinical applications such as vaccines, antibodies and pharmaceuticals. The physiology of these cells is very sensitive, leading to the need of sophisticated process technology. This application note demonstrates the use of a combination of Hamilton sensors (pH, dissolved oxygen, optical density and capacitance measurements) to analyze accurate and reliable online (inside the bioreactor) process monitoring and control.