Copy Number Variation Analysis Using the QuantStudio® 3D Digital PCR System

In this application note Thermo Fisher demonstrates the measurement of genes at low and high copy numbers with the QuantStudio® 3D system. Copy number variation (CNV) is an imbalance in the genome which increases or decreases the wild type copy number of a locus in comparison to a reference genome. These genomic alterations have been implicated in many diseases, including cancer.