Elephas Live™ Method: A sequential approach to tackle tissue scarcity and heterogeneity in live tumor fragments

This white paper presents a rigorous evaluation of the Elephas Live^™ Method, a sequential ex vivo treatment approach designed to overcome tissue scarcity and intratumor heterogeneity in core needle biopsy–derived live tumor fragments. Through multiplex cytokine profiling across diverse tumor types, the paper demonstrates how this scalable platform distinguishes immunotherapy responders from non-responders and provides a framework to support clinical trial stratification and therapeutic decision-making.