Enhanced assessment of nanoparticle colloidal . stability via FFF-PALS

Zeta potential (ZP), a measure of net charge in solution, is widely used to assess the colloidal stability of nanoparticle drug delivery systems. This application note describes a novel technique, FFF-PALS, which quantifies distributions of nanoparticles by size and ZP to a high resolution and how results can be validated with SEC-PALS, using Wyatt technology. There is also potential to add additional characterization techniques in-line such as spectroscopic, conformational or thermal analysis.