Enhancing the Analytical Capabilities of DESI Imaging using Ion Mobility Separation

Matrix assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) coupled with ion mobility separation has demonstrated significant utility over the last decade for the separation of matrix ion species from endogenous ion species in the gas phase. Desorption electrospray ionization (DESI) has been gathering momentum as a complementary MSI technique to the more traditional SIMS and MALDI-MS approached. This poster compares and contrasts DESI imaging with MALDI imaging on the same ion mobility enabled mass spectrometer.