Expression and intracellular translocation of cancer biomarkers in hepatocarcinoma cells induced by changes in mitochondrial metabolism

Hepatocarcinoma is one of the most common cancer types in the U.S. with limited treatment options and poor survival rate. The identification of relevant biomarkers is essential for screening and validation of small molecules proposed as chemotherapeutic agents. In this application note, Agilent discusses the development and validation of quantifiable, simple, and fast methods for screening anticancer drug candidates (small molecules) in tumor cell cultures.