Fast UHPLC-MS/MS Method to Simultaneously Quantify Erlotinib, OSI-420, Sunitinib, SU-12662, and Pazopanib in Dried Blood Spots (DBS)

Dried blood spot (DBS) sample collection can facilitate blood sampling for both patients and medical staff. From a technical perspective, analysis of DBS is a challenging task and handling of a high number of DBS cards following the manual procedure is time consuming and error prone. In this study, automated on-line DBS extraction was performed using a CAMAG DBS-MS 500 autosampler.