hERG Safety Screening Assay Using the IonWorks HT System

This application note describes the use of the IonWorks HT System to test the effects of compounds on the hERG potassium channel. A mock hERG screening experiment was performed on the IonWorks HT System by randomly including hERG channel inhibitors (dofetilide, E-4031, terfenadine) among mock “unknowns.”