High-throughput screening of formulation and process conditions for LNP synthesis

In this poster, Particle Works presents its work on high-throughput screening of formulations and process conditions for lipid nanoparticles (LNPs). The company has developed the Automated Library Synthesis (ALiS) system, which combines automation, precision, and reusable microfluidic chips to enable rapid preparation and processing of LNP formulations. The system demonstrates excellent consistency in LNP synthesis and recovery from poor formulations through effective cleaning between samples. By using its microfluidic chips, Particle Works achieves precise control over particle formation and fine-tuning of mixing conditions. The results highlight the advantages of using specific lipid formulations for smaller particle size and lower polydispersity index.