iCell Cardiomyocytes: Assaying Mitochondrial Membrane Potential

The compromise of mitochondrial function and ATP production can have significant impact on tissues with high-energy demands like the heart. Because cardiotoxicity is a major concern in drug development, it is critical to screen candidate drugs doer their effects on mitochondrial membrane potential. This application note describes how iCell® Cardiomyocytes, from Cellular Dynamics International, are an amenable cellular platform for in vitro toxicity assays investigating the integrity of the mitochondrial membrane potential.