Image-Based Analysis of a Human Neurosphere Stem Cell Model for the Evaluation of Potential Neurotoxicants

Pollution in the environment can lead to a buildup of toxic chemicals detrimental to human health, the developing nervous system in particular is very susceptible to toxicant exposure. Testing the effect of chemicals on the nervous system to better understand the cause and effect can be time and cost consuming when using animal models, this application demonstrates a 3D neurosphere model composed of human neural stem cells (hNSCs) used for toxicity testing. This system can reduce cost and the amount of animal experimentation, while still providing useful results.