Imaging of Tumor Growth and Metastasis in a Pancreatic Cancer Mouse Model

Mouse models have been developed for use in cancer research to investigate antitumor response and its role in disease progression, as well as to predict efficacy and find toxicities for cancer chemotherapeutic agents prior to beginning a clinical test. Among mouse models, human tumor xenograft has become the most common. In this model, human tumor cells are transplanted into immunocompromised mice which do not reject human cells, either under the skin or directly into the organ in which the tumor originated. In this application note, the tumor in a pancreatic cancer model was visualized in vivo using the UVP iBox® Scientia™ Imaging System.