In-depth analysis of non-derivatized N-linked glycans using ion chromatography-orbitrap mass spectrometry

The development of reliable, high-throughput workflows for analysis of N-linked glycans is required in the biopharmaceutical industry. In this scientific poster, Thermo Fisher Scientific reports a novel method that couples high-performance anion-exchange chromatography and pulsed amperometric detection (HPAEPAD) to a Q Exactive mass spectrometer, a workflow that promises the fast release and subsequent analysis of N-linked glycans.