Intra-Tumour Heterogeneity in Prostate Cancer and the Implication in CTC Analysis using the Pasortix System

Isolation of circulating tumour cells (CTCs) from peripheral blood has the potential to provide a far easier ‘liquid biopsy’ than tumour tissue biopsies, to monitor tumour cell populations during disease progression and in response to therapies. This scientific poster describes the use of the Pasortix System in a study aimed to identify the heterogeneous expression of epithelial and mesenchymal markers in a metastatic prostate cancer cell line and to investigate the intra-patient heterogeneity of these sub-populations of circulating cells isolated by a size-based system.