iPSC-derived motor neurons and microglia from ALS background display disease phenotype

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder caused by the degeneration of motor neurons, and ultimately results in death. In this whitepaper from Sartorius, explore how fibroblasts taken from a healthy individual and an ALS patient carrying a C9orf72 hexanucleotide expansion were reprogrammed to induced pluripotent stem cells, and then differentiated to motor neurons and microglia alongside controls. Results have displayed that this can be used as a robust model for C9orf72 ALS research and drug discovery.