Knock-out cell lines: A comprehensive guide to use and benefits

Gene knock-out (KO) technology and the generation of KO cell lines has been an essential tool in biology for studying genes of unknown function. However, the advent of CRISPR-Cas9 KO technology is expanding the range of cell lines available for research far beyond previous offerings, rendering them cheaper and more reliable through advancements such as direct injection.

This eBook provides an informative guide on how ready-made KO cell lines benefit workflows, provide quality control, and deliver confidence in results. Download now for insights including:

• The importance of robust KO validation
• Sourcing the right KO cell lines for your program
• gRNAs for increased gene-editing success
• Investigating signaling pathways such as PD-L1 and TRAIL