Labeling and In Vivo Localization of Ovarian Cancer Cells Using a Near IR Probe and a Multimodality Imaging System

This application note describes the use of NIR nanoparticle probes for in vivo imaging of metastatic ovarian cancer models. The system is highly efficient for labelling cells, and it is retained for several passages without any observed toxicity. Following injection into the mouse, labelled tumors were detected after three weeks. Visualization of multiple sites around the animals was enhanced with the use of MARS.