Magnetic Enrichment of Antigen-Specific CD4+ T Cells Using the MACSQuant Analyzer 10

Follicular T helper cells (Tfh) play a crucial role in supporting germinal center induction and responses by providing B cell help needed for affinity maturation and generation of B cell memory. Circulating (cTfh) have moved to the center stage of immunological research since it becomes increasingly apparent that these cells are providing insights into the immune responses occurring in the germinal centers of lymphoid organs. Typically, these lymphatic tissues are not accessible when studying human immune responses, thus making cTfh an attractive target for surrogate markers of immunity.