Multiplexed High Content Hepatotoxicity Assays using Induced Pluripotent Stem Cell Derived Hepatocytes

Hepatotoxicity is one of the main safety concerns in drug development. Highly predictive in vitro assays suitable for safety and efficacy testing are extremely important for improving the drug development process and reducing drug attrition. Accordingly, there is great interest in using stem cells as tools for screening compounds during early drug development. In this poster learn about several models for assessing general and specific hepatotoxicity that are well-suited for automated assays. The results demonstrate that method has potentially significant value for compound screening and early safety evaluation in drug development process.