Non-Invasive, in vivo Bioluminescence Imaging of Myeloperoxidase Activity in a Psoriasis-like Mouse Model

This application note describes a mouse dermatitis study whereby in vivo phagocyte-mediated myeloperoxydase (MPO) activity was monitored non-invasively by detecting a bioluminescent signal resulting from MPO-specific luminol catabolism. MPOluminol bioluminescence signal is known to be co-localized with histological sites of inflammation as well as infiltration of neutrophils and activated eosinophils.