Novel Tumor Targeting Near Infrared Fluorescent Probes

This application note by Caliper Life Sciences evaluates the pharmacokinetic/pharmacodynamic profile of fluorescent probes using optical imaging. HER2-targeting agents are labeled with NIR dyes for fluorescence detection. In vivo imaging shows tumor targeting at 3 hours after intravenous injection in a subcutaneous SKOV3 tumor model. HER2 has become an important prognostic and predictive factor, as well as a target for molecular therapies, in specific types of breast cancer.