Paper spray ionization: The faster path to mass spec analysis

Common concerns with using conventional chromatography-based mass spectrometry (MS) include time-consuming protocols, experiment backlogs, high costs per sample, equipment downtime for maintenance and the need for experienced technicians.

Using paper spray ionization techniques, and the Thermo Scientific^™ VeriSpray^™ PaperSpray ion source, researchers in clinical and forensic toxicology labs with high-throughput requirements can now perform direct mass spectrometry-based analyses with minimal solvent consumption and sample prep, thereby saving costs per test and reducing the time involved.

In this eBook, we provide case studies and proof-of-concept experiments that corroborate the varied benefits of employing paper spray ionization methods, and cover:

• Detection of controlled substances in blood samples
• Quantitative analysis of antifungal drugs
• Robustness characterization of quantitative whole blood assays
• Quantification of immunosuppressants in whole blood
• Improving the limit of quantification in clinical research
• Analysis of immunosuppressant drugs
• Quantitative analysis of EDDP
• Drugs of abuse screening and quantification