Profiling a Structure Activity Relationship (SAR) Library for Immunological Activity in Human PBMCs

Immunotherapy has the potential of affecting – positively and negatively – the interactions among cells and signaling molecules regulating the immune system. This poster highlights a no-wash high throughput screen of a Structure Activity Relationship (SAR) expansion library of immune-modulatory compounds using a PBMC-based assay. The multiplexing capabilities of the IntelliCyt iQue Screener platform allowed for multiple, immune-relevant parameters to be gathered in a single plate read thus generating activity profiles that can be used for identifying viable therapeutic candidates.