Profiling Immunosuppresants in Primary Human PBMCs on the iQue Screener

A potential side effect of therapeutic drugs is adverse effects on the functionality of the immune system. Performing cell based assays in high throughput screening environments offers the possibility of identifying compounds with cellular immunotoxicity profiles early in the drug discovery process. This application note demonstrates the use of a multiplexed screening assay on the iQue Screener to characterize differential responses of peripheral blood mononuclear cells (PBMCs) to immunosuppressants.