Quality control of oligonucleotides with a single quadrupole mass spectrometer

In this application note, Thermo Fisher Scientific presents two workflows for data analysis. Both use the peak area of UV and MS detection for determining the relative abundance of the analyte within the sample. However, the first workflow determines the identity of the analyte by its most intense m/z species. The second one uses deconvolution of the mass spectrum for mass determination and analyte identification.