Quantification of Crystallinity Using Transmission Raman Spectroscopy

The crystallinity of an active pharmaceutical ingredient (API) may affect its bio‑availability and its overall patient efficacy. It is critical to be able to measure the crystalline content of a final drug product. Transmission Raman spectroscopy (TRS) can differentiate and quantify crystalline and amorphous API. Measurements are fast, and the transmission sampling geometry ensures that the signal obtained is representative of the bulk, and not biased to the surface