Quantitation of 22 fentanyl analog compounds on an Orbitrap Exploris 120 mass spectrometer

In this application note from Thermo Fisher Scientific, explore a method for quantitation of the Traceable Opioid Material™ (TOM) kit compounds in urine that includes sample preparation by supported liquid extraction (SLE), quantitation by full scan high-resolution accurate mass (HRAM) data, and confident confirmation by retention time, accurate m/z, isotopic pattern matching and experimental matching of collected MS² spectra to an in-house MS² library of 213 fentanyl analog compounds.