ResourceLife Sciences
Rapid and reproducible parallel processing of charge heterogeneity analysis of protein therapeutics by multi-capillary isoelectric focusing
5 Nov 2021In this application note, a parallel capillary isoelectric focusing analysis using the BioPhase 8800 system and a multi-capillary separation approach is described. Protein therapeutic charge variant assessment is essential at different manufacturing stages as they are subjected to instability, causing alterations in their primary amino acid sequence.