Recent Advances for Seeding a Crystallization Process

Seeding has become one of the most critical steps in optimizing crystallization behavior, process efficiency, and product quality. Inconsistent filtration rates, drying times, yields, bulk density, flow properties, and particle size distributions can often be traced back to inconsistent seeding and nucleation. This white paper describes a best practice approach for designing a seeding strategy and discusses recent publications on advanced seeding techniques with real time feedback control of the particle size distribution.