Relative Viscosity Measurement Using the UNit

Characterizing the viscosity of biologic formulations is a critical part of formulation development as the viscosity can have an impact on bioprocessing as well as final administration of the biologic. The UNit with the optional 445 nm laser enables the relative viscosity measurement and retains the 266 and the 473 nm lasers, thus retaining its capability to simultaneously measure conformational stability and aggregation propensity of samples. In this application note, we demonstrate the use of the UNit with the optional 445 laser in combination with a fluorescent molecular rotor to screen relative viscosities of samples in a high throughput manner.