Removal of Non-volatile Solvents with RediSep Rf Gold®C18Aq Columns

Samples are often dissolved in non-volatile solvents, such as DMF and DMSO, for experiments such as NMR studies. Recovery of the sample from these solvents is difficult because of the solvent’s high boiling point. In this application note, the RediSep Rf Gold® C18Aq columns are used to retain the desired compound while removing the non-volatile solvent. The compound is then released using a solvent with a lower boiling point that is more easily evaporated. This method allows the recovery of valuable material for further experiments.