Screening Reactive Oxygen Species on the iQue Screener

At high concentrations ROS cause oxidative stress and are destructive to lipids, DNA and proteins. Excessive amounts have been linked with numerous diseases such as cancer, cardiovascular disease and hearing loss. Early, rapid and easy identification of compounds that cause increases in ROS would be a valuable component to a drug discovery and development program. In this application note, the iQue Screener was used to simultaneously detect levels of ROS and superoxide in multiple cell lines.