Simultaneous Quantitative Peptide Mapping and Host Cell Protein Detection in a Recombinant IgG1 Monoclonal Antibody Preparation using Data-Independent Acquisition

Monoclonal antibodies (mAb) are major target-oriented biotherapeutics used to treat an array of human diseases. This poster explores the application of an unbiased and deterministic, data-independent method for mAb analysis using SWATH™. This approach provides substantial benefits over other MS strategies because it captures comprehensive, quantitative MS and MS/MS information for every analyte in the sample, in every analytical run.