The Theory and Practice behind Differential Scanning Calorimetry

The ability to characterize native biomolecules is a key benefit of using differential scanning calorimetry (DSC); a technique based on heat measurements. Furthermore, the lack of spectroscopic readings means that samples do not have to be optically clear. The theory and practice behind DSC is explained in this white paper from Malvern Instruments. DSC is explained using the MicroCal VP-Capillary DSC; highly sensitive, fully automated, high-throughput differential scanning calorimeter for characterizing protein and biomolecule stability.