Transmission FT-NIR Analysis for the Simultaneous Analysis of Carbamazepine and PEG 2000 in Extrudates

In this application note, FT-NIR spectroscopy was successfully applied to the characterization of clear extrudates consisting of a drug, polymer and plasticizer, in order to quantify both drug and plasticizer content. This study has demonstrated the feasibility of monitoring levels of API and plasticizer components simultaneously and in real-time.