Understanding the Conformational Stability of Protein Therapeutics Using Raman Spectroscopy

The combination and integration of DLS and Raman spectroscopy into a single instrumental platform provides unique analytical capabilities to determine protein secondary and tertiary structure, melting temperature, size and onset of aggregation for the same sample without altering the testing conditions. This white paper describes describe the role of Raman spectroscopy in understanding the conformational stability of protein therapeutics, including the unique spectra-structure properties that may be correlated.