Use of iPSC-Derived Human Motor Neurons in High-Throughput Phenotypic Screening

There exists a dire need for more effective drugs to treat disorders of the central nervous system (CNS), and new cell culture models that are more relevant to psychiatric and neurological diseases are needed to improve the success rate of drug development programs. One such approach is the use of neurons differentiated from patient induced pluripotent stem cells (iPSCs), which present new opportunities for modeling disease processes and screening drug libraries.