Biopharmaceuticals: Oligonucleotide analysis, regulatory compliance, and more
Explore the latest research, expert insights, and new technology driving biopharmaceutical discovery and development
4 Apr 2022
As part of our latest special feature, we’ve pulled together a selection of top resources to streamline and advance your biopharmaceutical workflows.
Read on to learn about the technology optimizing analysis when characterizing complex biotherapeutics, find out how you can identify the best ion-pairing reagents for LC/MS analysis of oligonucleotides, explore the benefits of differential scanning calorimetry in vaccine development, and much more.
Plus, register for the Biopharmaceuticals Webinar Series, and catch up on all the latest webinars in the field that can benefit your research and workflows.
CHARACTERIZATION: Harnessing the power of label-free molecular interaction analysis
Dr. Kalhari Silva, Head of Scientific Innovation and Research at Custom Biologics, discusses the importance of binding studies in the analysis of complex biotherapeutics and how Octet BLI technology is streamlining analyses while meeting regulatory guidelines.
ION PAIRING: Optimize LC/MS analysis of oligonucleotides
In this application note, discover the variables associated with various ion-pairing reagents for LC/MS and learn how you can identify the best option for your oligonucleotide analyses.
DSC: Optimize and speed up vaccine development
In this guide, learn how differential scanning calorimetry (DSC) delivers high-standard stability and characterization data for protein subunits, viral particles, and virus-like particle vaccine candidates.
LC-HRMS: Sensitive analysis of antisense oligonucleotides
In this method, the antisense oligonucleotide Mipomersen is analyzed by LC-HRMS. Learn how the YMC-Triart C8 metal-free column enables symmetric peaks, high sensitivity, and no carry-over effects.
REGULATORY: Water purification for QC success
Form FDA 483s are an essential tool for maintaining high standards of quality management. In this white paper, ELGA LabWater explores this topic and the important role of water purity in meeting compliance requirements.
BISPECIFICS: Meet the challenges of anti-drug antibody assay development for bispecifics
This study explores the challenges in immunogenicity assay development for bispecific antibodies. Read on to learn how LGC's Drug Development Solutions scientists developed a sensitive, selective, specific, and drug-tolerant assay to meet regulatory requirements.
BIOSIMILARS: How biosimilars are expanding options for patient care
Heather Watson, Senior Manager in the Immunochemistry Department at Labcorp, explores the opportunities and challenges in biosimilar development as more biologics are going off-patent. Watson also describes why a mechanism of action (MOA)-reflective and biologically relevant assay is important in biosimilar characterization.
(U)HPLC: Method and tips to improve separation of biomolecules
In this application eBook, Tosoh Bioscience presents 20+ methods for biotherapeutic analysis, including protein aggregation, charge isoforms, and glycosylation, as well as the determination of the drug-to-antibody ratio of antibody-drug conjugates.
SINGLE-CELL ANALYSIS: Deep characterization of a CAR T-cell product
In this application note, explore how targeted single-cell transcriptomic profiling can help accelerate CAR T-cell therapy development by comprehensively characterizing infusion products, cell by cell.
Biopharmaceuticals Webinar Series
In this series of webinars, learn about the latest techniques and technologies streamlining biopharmaceutical discovery and development.
LC/MS: Overcome oligonucleotide analysis challenges with 2D-LC/MS
In this webinar on April 7, experts will discuss the common challenges associated with oligonucleotide analysis and purification and how to overcome them through 2D-LC/MS and method optimization.
SINGLE-CELL: Accelerating drug discovery and development with single-cell and spatial profiling
Join this webinar on April 20 to learn how researchers from pharma, biotech, and translational labs are leveraging 10x Genomics technologies throughout the drug discovery process to accelerate mechanistic understanding and reduce risk.
Additional biopharmaceutical resources:
Why functional assays are crucial for biopharmaceutical development success: In this webinar, learn how reporter-gene assays, in combination with complement system assays, can be used to determine drug mechanisms of action and the expected immune response. Register now>>
Robust analytical characterization: Accurate, reliable quantitation for biotherapeutics: In this interactive guide, explore some of the chromatographic applications for critical quality attribute monitoring within the most common bioanalysis workflows. Visit interactive hub>>
Trending in biopharma: From developing vaccines for pandemics to overcoming omic workflow bottlenecks: In this top list, explore a playlist of top interviews from The Scientists’ Channel. Watch exclusive interviews with industry experts on the key to vaccine development success, the role of biomaterials in creating drug models, and more. Read article>>
How to buy microplate readers: Microplate readers/detectors are the key workhorses in many laboratories and are used extensively for applications in drug discovery and assay development. In this free eBook download, we guide you through buying a new microplate reader by providing expert insight and the information you should consider when selecting the best technology for your lab. Download eBook>>
How to buy biophysical characterization technology: In this free eBook download, we take an in-depth look at the most common techniques used to quantify and characterize biophysical interactions. Plus, explore top tips from experts for choosing the best technologies to meet your characterization needs. Download eBook>>
Your recommendations:
Take a look at what other researchers all over the world are saying about the latest equipment and technologies helping scientists. Here, Luke Miles, Florey Institute of Neuroscience, shares his opinion on the Octet® R8 by Sartorius.
Find more news and resources in our Biopharmaceuticals Special Feature>>
