Definiens Expands Digital Pathology Solution with Gene Probe Analysis

Definiens has announced that Definiens Tissue Studio^® 3.5 now supports the automated analysis of in situ hybridization assays, including SISH, CISH, FISH and dual-ISH. This flexibility facilitates the detection of spot-like signals originating from gene probes (or any other stain with spot-like appearance) on a cell-by-cell basis. Definiens Tissue Studio^® supports the detection of gene probe signals in both brightfield and immunofluorescene imaging.

The novel functionality complements the robust detection of regions of interest, and the comprehensive quantification of cellular parameters and biomarker expression profiles. Definiens Tissue Studio^® can be used to analyze images from any solid tissue with any stain, acquired by any scanner or microscope, and in any common file format. With these technological advances, pathologists and researchers can adapt preconfigured solutions to their specific assays with just a few clicks in no more than 30 minutes.

Straightforward workflow, intuitive configuration, as well as flexibility and robustness of the Definiens Tissue Studio^® can significantly reduce study times in translational research, preclinical safety, tissue-based biomarker development and clinical trials around the world. The new version includes a range of improvements that make it easier to use and more powerful than ever.

“Definiens has developed significant experience in the analysis of in situ hybridization assays in recent years,” said Thomas Heydler, CEO of Definiens. “In Definiens Tissue Studio^® 3.5, we now make this available to our customers in a very easy-to-use workflow that supports virtually any type of 2D ISH assay. This further strengthens Definiens Tissue Studio^®’s position as the most comprehensive software package for quantitative digital pathology.”

With a single configuration, Definiens Tissue Studio^® automates the detection of regions of interest and has the capacity to distinguish individual cells and subcellular structures even in heterogeneous tissues samples. The software provides quantitative readouts on morphological characteristics and molecular expression profiles of nuclear, cytoplasmic and membrane biomarkers. In addition, Definiens Tissue Studio^® supports robust detection of vessels for automated angiogenesis assays as well as extensive multiplexing for the quantification of numerous parameters from the same tissue sample in immunofluorescence assays.

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