Products & ReviewLife Sciences
8-Bromo-cAMP
cAMP pathway activator; Activates cAMP-dependent kinase
8-Bromo-cAMP
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8-Bromo-cAMP is a membrane-permeable cAMP derivative. It can activate cAMP-dependent protein kinase, with long-acting effects due to its resistance to cAMP phosphodiesterase (Schwede et al.). It can be used to study calcium-mediated pathways (IC₅₀ = 0.84 mM; Xaus et al.).
REPROGRAMMING
- Improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells, in combination with valproic acid (Wang & Adjaye).
IMMUNOLOGY
- Inhibits M-CSF-dependent proliferation of macrophages (Xaus et al.).
- Protects neutrophils against TNF-α-induced apoptosis (Krakstad).
CANCER RESEARCH
- Induces a proliferative response in an IL-3-dependent leukemic cell line (Barge et al.).
- Induces membrane depolarization in pancreatic cancer cell lines (Sorio et al.).
