ACQUITY UPLC I-Class/Xevo TQ-S micro IVD System

Robust performance from a compact design for clinical laboratories
Robust performance begins in the source with ZSprayTM geometry, efficiently removing neutral molecules while drawing ions through the sample cone into the analyzer. The StepWaveTM ion guide in the Xevo TQ-S micro is designed to cope with the challenges in the modern clinical laboratory that are produced by high sample throughput and difficult matrices.

Neutrals and gas load are passively removed for enhanced transmission with the ions actively transferred into the mass analyzer, improving sensitivity and robustness. All this is achieved while maintaining an extremely small footprint due to the class-leading compact design of the Xevo TQ-S micro.

Acquire data points faster without without loss in sensitivity
Xccelerated Ion Transfer (XITTM) electronics, using SpaceWire technology allow this instrument to acquire data at extremely high speeds without compromising performance. The next generation T-WaveTM collision cell permits acquisition of 500 MRM channels/s whilst minimizing cross-talk and maintaining intensity. The increased MS full scan speed capability of up to 20,000 Da/s reduces the impact on the duty cycle when rapidly switching between MS full scan and MS/MS acquisition (RADAR and PICs).

In addition, fast polarity switching gives coverage of positive and negative ionizing compounds in a single injection. Maintaining performance at these speeds is critical as every clinical laboratory requires high quality data that is reproducible to enable reliable quantification. Method transfer is now even easier with the advanced XDR detector which provides unique Xtended Dynamic Range improving usability with low limits of detection.

Understanding sample complexity in clinical LC-MS/MS method development
Challenges for quantitative methods include:

• Performing targeted analysis for analytes of interest and detecting unexpected analytes in the same injection
• Characterization of background matrix for every sample throughout each run to improve data quality
• Examining matrix background during method development to better characterize targeted methods for interferences as well as ion enhancing and ion suppressing species

These challenges may be overcome by using RADAR which is the ability to obtain full scan (MS) and MRM (MS/MS) data simultaneously.

Comprehensive data processing with uncomplicated results review
Ready access to quantitative data and rapid review of data is essential in any clinical laboratory. The TargetLynx XSApplication Manager provides even more functionality, as well as the ability to perform standard addition to accurately calculate analyte concentrations. Building upon Waters flagship quantitative analysis package, the TargetLynx XS Application Manager provides ready access to quantitative data which is essential to any clinical laboratory. Years of iterative design have lead to an efficient workflow that supports rapid data review and reporting tools to ensure results reach their destinations as smoothly and as quickly as possible.

Features:

• Robust performance for reproducible detection of analytes at low levels in complex biological liquid sample matrices
• Confidence to quantify more analytes using high acquisition rates
• Accessible sensitivity and method transfer with the Xtended Dynamic Range (XDRTM) detector
• Understand sample complexity and improve method development with RADARTM
• Clinical laboratories now have access to the selectivity, sensitivity, and versatility of LC-MS/MS analysis not seen using traditional techniques
• Waters follows international quality standards with respect to its medical devices