Products & ReviewLife Sciences
AKT Inhibitor X
PI3K/AKT pathway inhibitor; Inhibits AKT
AKT Inhibitor X (Hydrochloride)
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AKT Inhibitor X is a cell-permeable phenoxazine-derivative inhibitor of AKT kinase phosphorylation with an IC₅₀ of ~1 - 2 μM. AKT Inhibitor X blocks translocation of AKT after insulin-like growth factor 1 (IGF-1) treatment (Thimmaiah et al.). This product is supplied as the hydrochloride salt of the molecule.
CANCER RESEARCH
- Inhibits growth and induces apoptosis of human rhabdomyosarcoma cell lines (Thimmaiah et al.).
- Inhibits proliferation of breast cancer cell lines, alone or synergistically with chloroquine (Hu et al.).
- Reduces replication of Myxoma virus in a variety of human tumor cell lines (Werden & McFadden).
DISEASE MODELING
- Induces autophagy in neurons and is neuroprotective in a primary neuronal Huntington Disease cellular model (Tsvetkov et al.).
