Allegro™ Connect buffer management system
Provides in-line dilution of buffer at point of use.
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The Allegro™ Connect buffer management system provides buffer on demand. It is a flexible system designed for pilot scale, clinical batches and commercial production to ensure that the right buffer is delivered at the right time, providing an efficient, streamlined workflow. The modular system design enables up to six high volume process buffers to be supplied as required, one at a time, directly to the batch unit operation such as chromatography or tangential flow filtration (TFF) based on buffer inline-dilution (ILD) and utilizing a single-use flow path. Multi-column chromatography (MCC) application buffer requirements can also be met by the Allegro™ Connect buffer management system, delivering a maximum of four process buffers at the same time to the MCC chromatography system.
- Buffer solution requirements per batch versus product titer and bioreactor volume
- Streamlined, efficient workflow
- Flexible design for multiple applications
- Up to 75% footprint reduction
- Utilizing single-use technology for maximum productivity
- Process flexibility
The Allegro™ Connect buffer management system has been designed to simplify and improve process buffer workflow by providing ‘just-in-time’ process buffer directly to the unit operation. Valuable floorspace is saved by using in-line dilution of buffer concentrates and water for injection (WFI) at point of use, to meet the target buffer specifications. Buffer workflow is simplified by eliminating the need to prepare and store large volumes of process buffer in advance. Operator workspace is improved with a more compact footprint around unit operations requiring high buffer volumes. Total buffer cost/L is reduced by up to 12%, attributable to a reduction in costs for labor, reagents and capex expenditure. The reduction in the overall footprint of buffer preparation/hold and storage vessels enables up to 75% valuable facility floor space savings.
The system has an additional option for bioburden protection, providing increased assurance against microbial contamination. Each in-specification buffer can be filtered prior to filling the process bag, with up to six single-use capsule filters with automated capsule venting to ensure ease-of-use. Additional protection can be achieved by using single-use manifolds with sterile connectors to maintain a low bioburden.
