Anti-GABPA Antibody
Detect GABPA using this Anti-GABPA Antibody validated for use in Western Blotting and Chromatin Immunoprecipitation (ChIP).
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Works for IP. Less sensitive for Western Blot.
Immunoprecipiation, Western blot
It works for IP at the dilution suggested. For Western Blot it's not very powerful. Weak signal, however clean (no background). Needs to be used concentrated (1:250-1:500).
Review Date: 9 Aug 2019 | Merck KGaA, Darmstadt, Germany
GA-binding protein alpha chain (UniProt Q00422; also known as GA repeat binding protein alpha, GABP subunit alpha, GABPalpha, NRF-2, Nuclear respiratory factor-2) is encoded by the Gabpa gene (also known as E4tf1a) in murine species (Gene ID 14390). GABPalpha is a redox-responsive transcription factor that plays an anti-oxidant, pro-survival role in mitochondrial biogenesis process. GABPalpha is upregulated in response to oxidant exposure or increased cellular reactive oxygen species (ROS), where it mediates the transcription of mitochondrial transcription factor A (mtTFA) that is needed for mitochondrial DNA transcription.
