Glen UnySupport
Universal CPG solid support for oligonucleotide synthesis
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Glen UnySupport™ is a universal support based on a conformationally preorganized molecule to accelerate the dephosphorylation reaction. The N-phenyl version, developed at Isis Pharmaceuticals as UnyLinker™, is available from several companies for large scale oligonucleotide synthesis. Glen UnySupport™ is the N-methyl version, which is preferred for high throughput oligonucleotide synthesis since methylamine rather than aniline is formed on deprotection. Higher angstrom universal supports are ideal for long syntheses (>150 mer) and can be utilized with modifier phosphoramidites for which 2000Å supports are not readily available.
