HMC3 (ATCC® CRL-3304™)
Organism: Homo sapiens, human / Cell Type: microglia / Tissue: brain / https://www.lgcstandards-atcc.org/Products/Cells_and_Microorganisms/By_Tissue/Brain/CRL-3304.aspx?geo_country=gb#generalinformation
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Good for immune response evaluation
Useful to study immune response in human brain.
This kind of cells are useful to study immune responses in human brain, respond to LPS (S. Typhi) producing and secreting the cytokine IL-6. Express microglial activation markers such as CD-68. CD11B, HLA-DR.
Review Date: 9 Apr 2024 | American Type Culture Collection (ATCC)
Microglial cells that could be a promise are not
Microglial Cells that are good for only so many passages
Unfortunately, finding a microglial cell line is difficult and expensive. Our group attempted to use a commercial cell line, the ATCC HMC3 cells. They use EMEM instead of DMEM otherwise not too difficult to work with. They do not grow all that fast but they do proliferate over time. The problem though, is that both of the users in the laboratory noticed that after about passage 9, they do not look healthy. This is from two independent researchers, if they did not cost so much this would not be a major issue but they are incredibly expensive. Not great.
Review Date: 4 Dec 2017 | American Type Culture Collection (ATCC)
Organism: Homo sapiens, human / Cell Type: microglia / Tissue: brain /
https://www.lgcstandards-atcc.org/Products/Cells_and_Microorganisms/By_Tissue/Brain/CRL-3304.aspx?geo_country=gb#generalinformation
