Index Crystallization Screen
Index is designed as a 96 reagent crystallization screen that combines the strategies of the grid, sparse matrix, and incomplete factorial screening with traditional, contemporary, and new crystallization reagent systems into a highly effective and efficient format. Index, as the name implies, efficiently samples a series of specially formulated reagent zones to identify which reagent class or classes and pH are effective in…
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Streamline screening
Crystallography
Hampton research offers many ion screens for peptide/protein crystallography. The ease of use and the speed of implementation after receiving the screens makes screening much more streamlined.
Review Date: 29 Mar 2022 | Hampton Research
I got really nice crystals out of these series ( HR2130 ,HR2134), they are perfect
Kits are designed to provide a highly effective and rapid screening method for the crystallization o
Every time that I used hr2-130 and hr2-134 crystallization screen to crystalize my proteins, I get lots of crystals which most of them are protein crystals. they have several varieties of conditions which are so good for initial screens.
Review Date: 5 Jul 2018 | Hampton Research
Sample Handling And Quality
Index HT formulated by Hampton Research is good for screening the initial crystallization. It is also useful for finding a good solubility solution for the protein of interest. This screen contains 96 solutions with different concentration of salts and also with varying pHs. This is very good screen for finding the initial crystallization condition for a protein. Besides crystallization these screens provide an excellent opportunity to find a good buffer for the protein of interest. I recommend these screen to be used for both crystallization and checking solubility of the protein of interest.
Review Date: 8 Jan 2014 | Hampton Research
Index is designed as a 96 reagent crystallization screen that combines the strategies of the grid, sparse matrix, and incomplete factorial screening with traditional, contemporary, and new crystallization reagent systems into a highly effective and efficient format.
Index, as the name implies, efficiently samples a series of specially formulated reagent zones to identify which reagent class or classes and pH are effective in producing crystals or limiting sample solubility.
Results from Index can be used to design optimization experiments and to identify follow on screens by reagent class. For example, positive results with salt based reagent in Index may be followed up with further screening using SaltRx or Grid Screen Salt. Success with polymer based reagents in Index may be followed up with further screening using PEGRx or PEG/Ion.
Index Crystallization Screen Features:
- A data-driven biased sparse matrix and grid screen
- Screens classic, contemporary, & modern crystallization reagents
- Samples pH 3 to 9
- Compatible with microbatch, vapor diffusion, & liquid diffusion methods
- Specially formulated reagent zones:
- Traditional salts versus pH
- Neutralized organic acids
- High [salt] with low [polymer]
- High [polymer] with low [salt]
- Low ionic strength versus pH
- PEG & Salt versus pH
- PEG & Salt - Tube or Deep Well block format
Applications:
- Primary, diverse reagent system crystallization screen for proteins, complexes, peptides, nucleic acids, & water soluble small molecules
