J774A.1 Cell Line from mouse
Cell Line Origin Mouse BALB/c monocyte macrophage Cell Line Description Derived from a tumour in a female BALB/c mouse. Cell line produces IL-5 and lysozyme. Application J774A.1 cell line has been used to test the cytotoxicity of [1,2,3]triazolo[1,5-a]pyridinium salts (having leishmanicidal activity) from triazolopyridines. It has also been used to determine the antitrypanosomatid activity of flavonoid glycoside…
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Cell culture (toxin neutralisation assay)
The cell has a good receptor for the toxin that we are assessing, and it does as expected if the vaccinated animal serum does not contain the neutralizing antibodies. It gives excellent results.
Review Date: 26 Feb 2020 | Merck
Cell Line Origin
Mouse BALB/c monocyte macrophage
Cell Line Description
Derived from a tumour in a female BALB/c mouse. Cell line produces IL-5 and lysozyme.
Application
J774A.1 cell line has been used to test the cytotoxicity of [1,2,3]triazolo[1,5-a]pyridinium salts (having leishmanicidal activity) from triazolopyridines. It has also been used to determine the antitrypanosomatid activity of flavonoid glycosides isolated from Delphinium sps.